International Journal of Advanced Biological and Biomedical Research

Effects of Jicama- (Pachyehizus erous) Based Oral Rehydration Solution on Intestinal Alkaline Phosphatase in Diarrheagenic Rats

Olumakinde Charles Omiyale; Mubaraq Damilare Yussuf; Esther Omolabake Kehinde; Oluwatoyin Olabimpe Olofin

Volume 12, Issue 2 , April 2024, , Pages 130-140

https://doi.org/10.48309/ijabbr.2024.2017216.1472

Abstract

Diarrhea results in the disruption of intestinal architecture and marked decrease in the activity of intestinal brush border enzymes, including Alkaline phosphatase (ALP). This study ... Read More

Hypoglycemic and Antioxidants Activities of Carica Papaya Leaves

Olumakinde Charles Omiyale; Blessing Ifeoluwa Ogunniran; Mercy Ogochukwu Ezeh; Mubaraq Damilare Yussuf; Confidence Damian Oparah; Fawaz Isshak

Volume 12, Issue 2 , April 2024, , Pages 141-154

https://doi.org/10.48309/ijabbr.2024.2017219.1473

Abstract

The objective of the current study was to assess the ethanolic and methanolic extracts of Carica papaya's hypoglycemic effects. Yeast glucose uptake, muscle glucose uptake, and glucose ... Read More

Lipophilic Vitamins (D and E) and Flavonoids (Quercetin and Naringin) Attenuate the Effects of Dichlorvos Toxicity on Catalase Activity

Mubaraq Damilare Yussuf; Alowoeshin Oluwaseun Samuel; Umoren Dayo Otoh; Irimoren Osaruese Emmanuella; Ike Chigozie Okechukwu; Sulaimon Olajuwon Abdul; Okafor Chukwudi Stanley; Adenike Okunade Ambrose; Olamide Tayo Akintola; Hannah Aderinsola Osibodu; Omeiza Momoh; Dayo Abdulwaheed Soleye

Volume 12, Issue 1 , January 2024, , Pages 67-91

https://doi.org/10.48309/ijabbr.2024.2015198.1470

Abstract

[Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is an organophosphate pesticide and insecticide used all over the world. Catalase is an enzyme that is responsible for degrading hydrogen ... Read More [Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is an organophosphate pesticide and insecticide used all over the world. Catalase is an enzyme that is responsible for degrading hydrogen peroxides present in organs or blood cells and tissue to prevent oxidative damage to these respected organs. The flavonoids (naringin and quercetin) and vitamin D and E have been found to reduce oxidative stress in the body. The study was carried out to detect the effect of specific lipophilic vitamins, naringin, and quercetin on catalase activity in the presence of a dichlorvos induced system. 112 male rats were divided into 14 groups of 8 rats each grouped as positive and negative control groups, dichlorvos only induced groups (2 groups), vitamins only induced groups (vitamin D and vitamin E), flavonoids only induced groups (quercetin and naringin), dichlorvos + vitamins administered groups (2 group each containing a different vitamin administration), and dichlorvos + flavonoids administered groups, baseline group and DMSO4 group. They were administered the dichlorvos for two weeks, and subsequent administration of vitamin D and E with naringin and quercetin respectively two weeks after. The animals were weighed every three days and were sacrificed immediately after administration, plasma and RBC along with the organs (liver and brain) were used to assess the effects of the vitamins and phytochemicals antioxidant capacity on catalase activity of the animals. Results showed that specific vitamin D, naringin, and quercetin were most important in their antioxidant capacity and helped improved catalase activity of initially treated dichlorvos group in some organs and compartments with the brain and red blood cells mostly benefitting from it with dichlorvos + vitamin D group, and vitamin D group having an SEM of 0.141±0.0044 and 0.150±0.00069, respectively, in the red blood cells. Meanwhile, the phytochemicals (naringin and quercetin) were more prominent in attenuating catalase activity in the brain with dichlorvos + naringin group and naringin group recording an SEM of 2.216±0.067 and 2.302±0.076, respectively, and dichlorvos + quercetin group and quercetin group recorded an SEM of 0.670±0.009 and 1.276±0.060, respectively. As a result, the fat-soluble vitamins, and phytochemicals reduced dichlorvos toxicity, but could not offer complete and absolute protection against the hydrogen peroxides and oxidative stress produced.

Phytochemical Profile and Antioxidant Properties of Extracts from Sargassum flutans

Omiyale Olumakinde Charles; Yussuf Mubaraq Damilare; Oparah Confidence Damian; Jokoh Peterkings Eriuroro; Ikuni Precious Ifechukwukuni; Okpara Chidiebere Cyril; Olofin Oluwatoyin Olabimpe; Ishiaq Abdulwasiu Dolapo; Ogunleye Felix Iyanu; Adeleye Hannah Oreoluwa

Volume 11, Issue 4 , October 2023, , Pages 261-276

https://doi.org/10.48309/ijabbr.2023.2010788.1460

Abstract

Many seaweeds, most notably brown algae, are suitable for human consumption. These plants have various possible biological actions and significant phytochemical components. The ethylacetate ... Read More

International Journal of Advanced Biological and Biomedical Research

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Author = Damilare, Yussuf Mubaraq

Effects of Jicama- (Pachyehizus erous) Based Oral Rehydration Solution on Intestinal Alkaline Phosphatase in Diarrheagenic Rats

Abstract

Hypoglycemic and Antioxidants Activities of Carica Papaya Leaves

Abstract

Lipophilic Vitamins (D and E) and Flavonoids (Quercetin and Naringin) Attenuate the Effects of Dichlorvos Toxicity on Catalase Activity

Abstract

Phytochemical Profile and Antioxidant Properties of Extracts from Sargassum flutans

Abstract